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COPD phenotypes model
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Chronic Obstructive Pulmonary Disease (COPD) is one of the leading cause of death worldwide and represents one of the major causes of chronic morbidity. Cigarette smoking is the most important risk factor for COPD. In these patients, the airflow limitation is caused by a mixture of small airways disease and parenchyma destruction, the relative contribution of which varies from person to person. The two-fold nature of this pathologic condition has been studied in the past and according to many authors each patient with COPD, although being the individual clinical expression of a wide and continuous spectrum of pathologic changes (different lesions may coexist) causing expiratory airflow limitation, should be classified as presenting a predominantly bronchial or emphysematous COPD phenotype by simple clinical, functional, and radiological findings.



Applications and models for COPD phenotype evaluation.

Our research group has recently developed and validated an applicative framework implementing multivariate models and other validated algorithms reflecting the specific predominant mechanism of airflow limitation in COPD patients (COPD phenotypes evaluation). The software applications were trained over a database of hundreds of patients and detailed explanation of the DB could be found in: "Pistolesi M, Camiciottoli G, Paoletti M et al. Identification of a predominant COPD phenotype in clinical practice. Respiratory Medicine 2008;102:367-376."
Please follow the link below to access the free on-line application implementing the model.


                               COPD phenotype estimation models and applications
 

 
 
  

CLinical Identification of Phenotypes in COPD, CLIP-COPD Project

UniversitÓ degli Studi di Firenze
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